Handheld Raman instruments are a valuable and well-recognized tool for cell culture media analysis in the biopharmaceutical industry. With the use of a Rigaku 1064 nm handheld Raman analyzer, the common issue of fluorescence interference is overcome. In addition, Progeny provides a versatile tool with enhanced features that allows it to be used for more than just material identification. This example shows the enhanced features available for spectral comparison, not only based on correlation, but also to compare two closely related materials and assess peak differences. Because of this, the Rigaku Progeny can be effectively utilized as a part of a complete quality analysis process in the biopharmaceutical industry.